Journal Article
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Long-term antireflux medication use following pediatric Nissen fundoplication.

Archives of Surgery 2008 September
HYPOTHESIS: Nissen fundoplication decreases the use of antireflux medications.

DESIGN: Retrospective cohort study using discharge abstract data and pharmacy data.

SETTING: Twelve regional Kaiser Permanente hospitals in southern California.

PATIENTS: Three hundred forty-two patients underwent Nissen fundoplication.

INTERVENTION: Nissen fundoplication.

MAIN OUTCOME MEASURE: Use of antireflux medications.

RESULTS: The number of patients requiring antireflux medications decreased from 233 patients (68.1%) before Nissen fundoplication to 197 (57.6%) after Nissen fundoplication. Of the 233 patients, 176 (75.6%) were restarted on antireflux medications within 1 year after Nissen fundoplication. Use of antireflux medication decreased in neurologically healthy patients but was unchanged in neurologically impaired children.

CONCLUSIONS: Use of antireflux medication decreased after Nissen fundoplication. Neurologically healthy children showed the biggest decrease in antireflux medication use after Nissen fundoplication.

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