JOURNAL ARTICLE

Live birth sex ratios are not influenced by blastocyst-stage embryo transfer

John M Csokmay, Micah J Hill, Frank V Cioppettini, Kathleen A Miller, Richard T Scott, John L Frattarelli
Fertility and Sterility 2009, 92 (3): 913-7
18774561

OBJECTIVE: To analyze the sex ratio of infants born after blastocyst-stage transfer of embryos with normal preimplantation FISH genetic screening.

DESIGN: Retrospective cohort analysis.

SETTING: Large academic assisted reproductive technology center.

PATIENT(S): Two hundred twenty-eight patients undergoing fresh IVF cycle with blastocyst transfer.

INTERVENTION(S): Preimplantation genetic screening for sex complement.

MAIN OUTCOME MEASURE(S): Sex ratio in liveborn infants following blastocyst transfer.

RESULT(S): One thousand thirteen embryos were normal by preimplantation genetic screening of chromosomes 13, 15, 16, 17, 18, 21, 22, X, and Y. Four hundred ninety-eight normal embryos were transferred to 228 patients with an overall live birth rate of 41.7%. Transferred blastocysts were selected based upon morphologic assessment. When controlling for the sex of the blastocyst embryo, there was no difference in the male-to-female delivery rate per embryo transferred (27.3% vs. 21.4%) (relative risk =1.28, confidence interval 0.93-1.74). Of the live births 51.7% were male and 48.3% were female (P=.61). Subanalysis revealed no difference in male-to-female delivery rates in groups with a 1:1 ratio of male:female embryos transferred, a non 1:1 ratio transferred, or single-sex transfers.

CONCLUSION(S): Blastocyst-stage embryo transfer does not influence the live birth sex ratio of embryos with normal preimplantation FISH genetic screening.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
18774561
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"