Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity

Jose M Miro, Carlos Cervera, Cristina Garcia-de-la-Maria, Ana Del Rio, Yolanda Armero, Carlos A Mestres, Jose M Grau, Francesc Marco, Asuncion Moreno
Scandinavian Journal of Infectious Diseases 2008, 40 (11-12): 968-72
We report a patient with Enterococcus faecalis native-valve endocarditis who relapsed after 4 weeks of treatment with ampicillin plus gentamicin. The relapse was cured with ampicillin plus ceftriaxone, which was introduced after gentamicin-induced acute renal failure. This double beta-lactam combination showed a bactericidal effect in time-killing curve studies.

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