Two new triterpenoid saponins from Gymnema sylvestre

Xu-Min Zhu, Ping Xie, Ying-Tong Di, Shu-Lin Peng, Li-Sheng Ding, Ming-Kui Wang
Journal of Integrative Plant Biology 2008, 50 (5): 589-92
Two new oleanane-type triterpenoid saponins, gymnemoside-W1 and W2, together with seven known compounds were isolated from the leaves of Gymnema sylvestre R. Br. By means of spectral and chemical analysis, the structures of the new compounds were elucidated as 16 beta-hydroxyl olean-12-en-3-O-[beta-D-glucopyranosyl (1-->6)-beta-D-glucopyranosyl]-28-O-beta-D-glucopyranoside(1) and 16 beta,21 beta,28-trihydroxyl-olean-12-ene-3-O-glucoronopyranoside (2). The EtOH/H(2)O extracts of this plant were shown to be able to inhibit glucose absorption in rats.

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