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JOURNAL ARTICLE

Chronic anterior uveitis following bacille Calmette-Guérin vaccination: molecular mimicry in action?

Alexander Spratt, Tim Key, Anthony J Vivian

Journal of Pediatric Ophthalmology and Strabismus 2008, 45 (4): 252-3

A 13-year-old girl developed bilateral chronic anterior uveitis following bacille Calmette-Guérin (BCG) vaccination. HLA testing was negative for B27 but positive for DRB1 *0404, a variant of DR4 often associated with rheumatoid arthritis. The authors propose her HLA repertoire allowed for a BCG-induced abnormal autoimmune response by the mechanism of molecular mimicry.

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