JOURNAL ARTICLE
REVIEW

[Does rocuronium displace the position of suxamethonium?]

Tomoki Sasakawa, Hiroshi Iwasaki
Masui. the Japanese Journal of Anesthesiology 2008, 57 (7): 860-8
18649641
A full stomach patient often requires a rapid sequence induction (RSI) technique to protect against gastric aspiration. Suxamethonium is the most common muscle relaxant used because it has a fast onset and a short duration. Unfortunately it can have serious side effects as a result of its membrane depolarizing effect and release of potassium. Rocuronium has been suggested to create intubating conditions similar to suxamethonium. However, it has been proved that suxamethonium creates superior intubation conditions to rocuronium in a large meta-analysis comparing intubation conditions. Once Org 25969 (sugammadex) is available to rapidly bind rocuronium and reverse its action, rocuronium may replace succinylcholine for rapid-sequence induction.

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