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Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus.

Fanny Ménard, Caroline Besson, Patricia Rincé, Olivier Lambotte, Thierry Lazure, Danielle Canioni, Olivier Hermine, Pierre Brousset, Antoine Martin, Philippe Gaulard, Martine Raphaël, Claire Larroche
Clinical Infectious Diseases 2008 August 16
The retrospective study of 34 patients with Hodgkin lymphoma-associated hemophagocytic syndrome led us to define this association as a specific disorder. Its characteristics are male predominance (male-to-female sex ratio, 3.3:1), immunodeficiency-like histological features (lymphocyte depletion, 45% of cases; mixed cellularity Hodgkin lymphoma subtype, 40%), and strong association with Epstein-Barr virus (94%).

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