[Dermatoporosis: an emerging syndrome]

G Kaya
Revue Médicale Suisse 2008 April 30, 4 (155): 1078-9, 1081-2
With the increase in lifespan, we are now more often experiencing a further dimension of skin aging, which is no longer only cosmetic, but also functional, in the sense that the skin has lost its protective mechanical functions. We propose to group the different manifestations and implications of this chronic cutaneous insufficiency/fragility syndrome under the umbrella term of "dermatoporosis". Molecular mechanisms implying hyaluronate-CD44 pathways seem to play an important role in the pathogenesis. Dermatologists should be aware of this emerging syndrome and function as key players in its prevention and therapy. Randomized clinical trials should demonstrate which intervention may best prevent and/or reverse dermatoporosis.

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