A new kid on the TGFbeta block: TAZ controls Smad nucleocytoplasmic shuttling

Katharine H Wrighton, Fangyan Dai, Xin-Hua Feng
Developmental Cell 2008, 15 (1): 8-10
A recent study from Varelas et al. in Nature Cell Biology reveals a role for the transcriptional regulator TAZ in TGFbeta signaling. Not only does TAZ couple phospho-Smads to the transcriptional machinery, it is also essential for their nuclear accumulation.

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