JOURNAL ARTICLE
REVIEW

Omega-3 polyunsaturated fatty acids in the treatment of schizophrenia

Malcolm Peet
Israel Journal of Psychiatry and related Sciences 2008, 45 (1): 19-25
18587166
Most studies have shown reduced levels of polyunsaturated fatty acids, particularly docosahexaenoic acid and arachidonic acid, in the cell membranes of red blood cells from schizophrenic patients. This has led to research interest in the possible therapeutic benefits of omega-3 fatty acids in schizophrenia. There is evidence from double-blind placebo-controlled trials that omega-3 fatty acids might prevent conversion from a prodromal state into first episode psychosis, and reduce the antipsychotic drug requirement in first episode patients. Results in chronic and acutely relapsing schizophrenia have been mixed. The problems associated with single nutrient studies are discussed. Nutrients are normally ingested in complex combinations, and they interact with each other in their normal metabolic and physiological functions. It is likely that optimal nutritional treatment will involve complex combinations of nutrients, preferably as part of a healthy balanced diet rather than by using supplements. However, such approaches have been little evaluated in mental health..

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
18587166
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"