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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
The safety of cetirizine during pregnancy. A prospective observational cohort study.
Reproductive Toxicology 2008 September
OBJECTIVE: To assess the safety of cetirizine during pregnancy.
STUDY DESIGN: A prospective observational cohort study with data of the Berlin teratology information center from 1992 until 2006. Pregnancy outcome was compared between a cohort of pregnant women exposed to cetirizine during the first trimester (n=196) and a control group not exposed to potential teratogens (n=1686).
RESULTS: Major birth defects were not more common in the study group than in the control group (OR 1.07; CI 0.21-3.59). We also compared the crude rate of spontaneous abortions (OR 0.97; CI 0.54-1.65), of preterm deliveries (OR 0.76; CI 0.35-1.5), and the birth weight of term newborns (p=0.13).
CONCLUSIONS: This prospective observational study on cetirizine in pregnancy suggests that the use of cetirizine is relatively safe during the first trimester.
STUDY DESIGN: A prospective observational cohort study with data of the Berlin teratology information center from 1992 until 2006. Pregnancy outcome was compared between a cohort of pregnant women exposed to cetirizine during the first trimester (n=196) and a control group not exposed to potential teratogens (n=1686).
RESULTS: Major birth defects were not more common in the study group than in the control group (OR 1.07; CI 0.21-3.59). We also compared the crude rate of spontaneous abortions (OR 0.97; CI 0.54-1.65), of preterm deliveries (OR 0.76; CI 0.35-1.5), and the birth weight of term newborns (p=0.13).
CONCLUSIONS: This prospective observational study on cetirizine in pregnancy suggests that the use of cetirizine is relatively safe during the first trimester.
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