Neutropenic enterocolitis: An unusual complication of HCV combination therapy with PEG-IFN and ribavirin

Krishna S Kasturi, Rajasekhara R Mummadi, Gagan K Sood
European Journal of Internal Medicine 2008, 19 (5): 372-3
Drug induced neutropenia as a consequence of intensive chemotherapy for hematological malignancies and solid tumors is known to be associated with severe, life-threatening infections such as neutropenic enterocolitis. However, the neutropenia associated with HCV combination therapy with Pegylated Interferon [PEG-IFN] and ribavirin is considered to be well tolerated in patients without other co-morbidities. We present a case of a severe gastrointestinal complication in a patient receiving HCV combination therapy and advocate caution in continuing therapy in patients with neutropenia, especially in the presence of underlying co-morbidities such as cirrhosis.

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