A study of anthropomorphic and biochemical characteristics in girls with central precocious puberty and thelarche variant

Pen-Hua Su, Shu-Li Wang, Jia-Yuh Chen, Suh-Jen Chen, Jui-Chen Ke
Journal of Pediatric Endocrinology & Metabolism: JPEM 2008, 21 (3): 213-20

BACKGROUND: Premature thelarche in later childhood may progress to central precocious puberty (CPP), which does not spontaneously resolve. Thelarche variant (TV) is a slowly progressive variant of precocious puberty.

AIM: To determine and compare levels of insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3) and anthropomorphic measures in girls with TV and CPP.

SUBJECTS: Prepubertal controls and girls with TV and CPP.

METHODS: Chronological and bone age, weight, height, BMI, height velocity (HV), and serum IGF-I, IGFBP-3, leptin, follicle-stimulating hormone (FSH) and lutenizing hormone (LH) levels were assessed.

RESULTS: Serum IGF-I levels, HV and IGF-I/ IGFBP-3 ratio were significantly higher in girls with CPP compared to both controls and girls with TV. IGFBP-3 values for bone age (IGFBP-3BA) were significantly higher in the TV group compared to both controls and girls with CPP. FSH and LH concentrations were significantly higher in the CPP group compared to TV.

CONCLUSION: HV, IGF-I, LH and FSH levels and IGF-I/IGFBP-3 ratio are elevated in girls with CPP compared to those with TV.

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