We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Advances toward understanding the molecular biology of the Anaplasma-tick interface.
The genus Anaplasma includes a diverse group of tick-borne pathogens found exclusively within membrane-bound vacuoles in host cells. While A. marginale, A. centrale and A. ovis, vectored by Dermacentor and Rhipicephalus ticks, are host-specific for ruminants, A. phagocytophilum, vectored by Ixodes spp., infects a wide range of hosts. In ticks Anaplasma undergoes a developmental cycle that is coordinated with the tick feeding cycle. Although research at the tick/Anaplasma interface is in its infancy, recent studies have provided evidence that Anaplasma infection and transmission is mediated by a molecular mechanism involving both tick cell and pathogen genes. Application of a growing array of molecular approaches, such as RNA interference, genomics and proteomics, are rapidly expanding our knowledge of the tick/pathogen interface. Targeting key tick cell molecules required for pathogen development in vaccine strategies may compromise the vector capacity of ticks for Anaplasma, thus reducing transmission and infection of vertebrates. Collectively, this information will likely lead to the development of dual target vaccines designed to protect vertebrates against tick infestations and prevent the transmission of pathogens.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app