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Anthelmintic acetogenin from Annona squamosa L. Seeds.

Marta M C Souza, Claudia M L Bevilaqua, Selene M Morais, Cícero T C Costa, Ana R A Silva, Raimundo Braz-Filho
Anais da Academia Brasileira de Ciências 2008 June
Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.

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