JOURNAL ARTICLE
REVIEW

[Kidney regeneration update]

Keiichi Hishikawa, Toshiro Fujita
Nihon Rinsho. Japanese Journal of Clinical Medicine 2008, 66 (5): 941-7
18464514
Functional recovery in acute renal failure is well known, and the adult kidney is generally recognized to have the capacity to regenerate and repair. Several groups have reported the contribution of bone marrow-derived cells in this process, and others have confirmed the existence of adult stem cells in the kidney, including label retaining cells, slow-cycling cells, side population cells, and rKS506 cells. However, recent data demonstrated that in vivo differentiation of bone marrow-derived cells into renal tubular cells may not occur at all, or is at most a minor component of the repair process. Moreover, it is now generally accepted that stem cells and multipotent cells contribute to the regenerative process by producing protective and regenerative factors rather than by directly differentiating to replace damaged cells. This review will focus on current understanding of kidney regeneration.

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