Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe

Ju Sin Kim, Sa Im Lee, Hye Won Park, Jae Heon Yang, Tae-Yong Shin, Youn-Chul Kim, Nam-In Baek, Sung-Hoon Kim, Sang Un Choi, Byoung-Mog Kwon, Kang-Hyun Leem, Mun Yhung Jung, Dae Keun Kim
Archives of Pharmacal Research 2008, 31 (4): 415-8
Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2).

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