OPEN IN READ APP
JOURNAL ARTICLE
MULTICENTER STUDY

Estimation of chromosomal imbalances in preimplantation embryos from preimplantation genetic diagnosis cycles of reciprocal translocations with or without acrocentric chromosomes

Chun Kyu Lim, Jae Won Cho, In Ok Song, Inn Soo Kang, Yong-Dal Yoon, Jin Hyun Jun
Fertility and Sterility 2008, 90 (6): 2144-51
18440525

OBJECTIVE: To estimate chromosomal imbalances in preimplantation embryos from reciprocal translocation carriers with or without acrocentric chromosomes (Acro-Ch) 13, 14, 15, 21, and 22 in preimplantation genetic diagnosis (PGD) cycles.

DESIGN: Fluorescence in situ hybridization was applied to PGD cycles for reciprocal translocation carriers.

SETTING: University-based centers for reproductive medicine.

PATIENT(S): Ten and 24 patients of reciprocal translocation with and without Acro-Ch, respectively.

INTERVENTION(S): Fluorescence in situ hybridization in biopsied blastomeres.

MAIN OUTCOME MEASURE(S): Estimation of meiotic segregation mode in embryos from translocation carriers.

RESULT(S): The proportion of alternative segregation for normal or balanced chromosome contents in preimplantation embryos from PGD cycles in reciprocal translocations without Acro-Ch was significantly higher than that with Acro-Ch (26.0% vs. 14.6%). The proportion of interchange trisomy in 3:1 segregation was significantly lower in reciprocal translocations without Acro-Ch than that with Acro-Ch (4.3% vs. 9.5%).

CONCLUSION(S): This is the first report that the incidence of alternative segregation producing normal or balanced embryos was relatively low in reciprocal translocations associated with Acro-Ch. Our data may be useful to predict the possibility of normal or balanced embryos and to counsel with reciprocal translocation carriers for PGD-fluorescence in situ hybridization cycles.

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read
18440525
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"