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JOURNAL ARTICLE
RESEARCH SUPPORT, N.I.H., EXTRAMURAL
VALIDATION STUDY
A sensitive HPLC-MS-MS method for the determination of raltegravir in human plasma.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2008 May 16
This work describes an assay system that has been developed to quantify raltegravir concentrations in human plasma using a liquid-liquid extraction technique paired with HPLC separation and MS-MS detection. The dynamic range of this assay extends from 1 to 3000 ng/mL, with a coefficient of determination (r(2), mean+/-SD) of 0.9992+/-0.0002. The mean precision values for calibration standards ranged from 0.6% to 3.0%, while accuracy values were 96.5-104.3%. This procedure is an accurate, precise, and sensitive method for raltegravir quantitation and was successfully validated using external proficiency testing.
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