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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Extracellular transglutaminase 2 activates beta-catenin signaling in calcifying vascular smooth muscle cells.
FEBS Letters 2008 April 31
Accumulation of transglutaminase 2 (TG2) is often associated with mineral deposits in vasculature. Here, we demonstrate that purified TG2 stimulated a 3-fold increase in matrix mineralization and up-regulation of osteoblastic markers in cultured primary vascular smooth muscle cells (VSMCs). Extracellular TG2 interacts with the low density lipoprotein related-protein 5 receptor and activates beta-catenin signaling in VSMCs. These results suggest that TG2 may promote vascular calcification by activating the beta-catenin signaling pathway.
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