JOURNAL ARTICLE

Molecular characterization of the E gene of dengue virus type 1 isolated in Guangdong province, China, in 2006

K Zheng, H-Q Zhou, J Yan, C-W Ke, A Maeda, J Maeda, I Takashima, I Kurane, H Ma, X-M Xie
Epidemiology and Infection 2009, 137 (1): 73-8
18387217
We determined the genetic relationships and origin of the dengue virus (DENV) responsible for an outbreak of dengue fever (DF) in Guangdong province, China, in 2006. Five DENV type 1 (DENV-1) isolates were obtained from human serum samples collected from DF patients during the outbreak. The nucleotide sequences of the E (envelope) gene were compared with those of 48 previous DENV-1 isolates: 18 from Guangdong province, one from Fujian province, one from Zhejiang province, and 28 from other countries in the South Asian region. The results suggested that four DENV-1 isolates identified in Guangdong province in 2006 might be in general circulation there, although these DENV-1 viruses may have been originally introduced into the province from other countries. In contrast, one isolate from Guangzhou city in 2006, may have been introduced by a recently imported case from Cambodia.

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