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COMPARATIVE STUDY
JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL

[Surgical or biologic sphincterotomy in the treatment of chronic anal fissure]

Slaven Suknaić, Leonardo Patrlj, Mario Steresinić, Andrija Skopljanac Macina, Lidija Erdelez
Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti 2008, 62 (1): 73-80
18365505

BACKGROUND: Chronic anal fissure is a lineal ulcer of the lower part of the anal canal. It is a painful condition characterized by postdefecational pain and bleeding. It is associated with internal anal sphincter spasm. The relief of internal anal sphincter spasm is the key for providing fissure healing. Gold standard in the treatment of chronic anal fissure is partial lateral internal anal sphincterotomy.

METHODS: Sixty patients with chronic anal fissure were randomly assigned into two groups treated either by surgical sphincterotomy or injections of botulinum toxin into internal anal sphincter. Manometric measurements were performed before and three months after treatment. Follow up period was six months. The aim of the study was to compare results between these two groups.

RESULTS: Both methods efficiently reduced resting anal pressure and successfully healed chronic anal fissure.

CONCLUSION: Surgical and biologic sphincterotomy are almost equally effective in the treatment of chronic anal fissure. Injecting botulinum toxin into internal anal sphincter is a safe, easy to apply and effective method in the management of anal fissure.

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