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COMPARATIVE STUDY
JOURNAL ARTICLE

Critical aspects of the Bayesian approach to phase I cancer trials

Beat Neuenschwander, Michael Branson, Thomas Gsponer
Statistics in Medicine 2008 June 15, 27 (13): 2420-39
18344187
The Bayesian approach to finding the maximum-tolerated dose in phase I cancer trials is discussed. The suggested approach relies on a realistic dose-toxicity model, allows one to include prior information, and supports clinical decision making by presenting within-trial information in a transparent way. The modeling and decision-making components are flexible enough to be extendable to more complex settings. Critical aspects are emphasized and a comparison with the continual reassessment method (CRM) is performed with data from an actual trial and a simulation study. The comparison revealed similar operating characteristics while avoiding some of the difficulties encountered in the actual trial when applying the CRM.

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