Cytotoxic diterpenoids from Euphorbia helioscopia

Zhi-Qiang Lu, Shu-Hong Guan, Xing-Nuo Li, Guang-Tong Chen, Jin-Qiang Zhang, Hui-Lian Huang, Xuan Liu, De-An Guo
Journal of Natural Products 2008, 71 (5): 873-6
Four new jatrophane-type diterpenoids (1-4), together with 16 known related compounds, were isolated from the Chinese medicinal plant Euphorbia helioscopia. The structures of 1-4 were determined on the basis of spectroscopic and chemical methods. Cytotoxicity of the isolated compounds against HeLa and MDA-MB-231 cells was evaluated, with only helioscopinolide A (5) and euphornin (3a) being active.

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