A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis

Atsushi Tanaka, Richard J Youle
Molecular Cell 2008 February 29, 29 (4): 409-10
DRP1, a member of the dynamin family of large GTPases, mediates mitochondrial fission. In a recent issue of Developmental Cell, Cassidy-Stone et al. (2008) identified mdivi-1, a new DRP1 inhibitor that prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during apoptosis.

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