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AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity.

A Janovská, G Hatzinikolas, V Staikopoulos, J McInerney, M Mano, G A Wittert
Molecular and Cellular Endocrinology 2008 March 13
Leptin stimulates fatty acid oxidation via the phosphorylation of AMPK (AMP-activated protein kinase) and ACC (acetyl-CoA carboxylase). Obesity is associated with resistance to the effects of leptin. We determined the action of leptin on AMPKalpha and ACCbeta phosphorylation and lipid metabolism in soleus (SOL) and extensor digitorum longus (EDL) muscles from lean and obese Wistar rats after 1 and 100 nM leptin. Both leptin doses stimulated phosphorylation of AMPKalpha and ACCbeta (P

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