PON1 activity and total oxidant status in patients with active pulmonary tuberculosis

Sahbettin Selek, Niyet Cosar, Abdurrahim Kocyigit, Ozcan Erel, Nurten Aksoy, Mehmet Gencer, Faruk Gunak, Mehmet Aslan
Clinical Biochemistry 2008, 41 (3): 140-4

OBJECTIVES: The aim of this study was to the investigate effect of tuberculosis infection on paraoxonase-1 (PON1) activity and oxidative status in patients with pulmonary tuberculosis (PTB).

DESIGN AND METHODS: Twenty-five active PTB subjects and 33 healthy controls were included in the study. Serum PON1 activity, total oxidant status (TOS), lipid hydroperoxide (LOOH) and total free sulfydryl (-SH) groups were determined.

RESULTS: Serum basal/salt-stimulated paraoxonase activities, arylesterase activity and total -SH group levels were significantly lower in patients with PTB than controls (p<0.05, p<0.05, p<0.001 and p<0.01 respectively), while TOS and LOOH levels were significantly higher (p<0.01 and p<0.05, respectively). In PTB patients, TOS, LOOH and total -SH group levels were significantly correlated with paraoxonase (r=-0.371, p<0.05; r=-0.286, p<0.05; r=0.625 p<0.01; respectively) and arylesterase (r=-0.437, p<0.01; r=-0.352, p<0.05; r=0.653, p<0.01; respectively).

CONCLUSIONS: Patients with active PTB are exposed to potent oxidative stress and they have decreased PON1 activity. These predisposal factors may, in part, play a role in the pathogenesis of atherosclerosis in PTB.

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