International Scientific Committee of Radionuclides in Nephrourology (ISCORN) consensus on renal transit time measurements

Emmanuel Durand, M Donald Blaufox, Keith E Britton, Ove Carlsen, Philip Cosgriff, Eugene Fine, John Fleming, Cyril Nimmon, Amy Piepsz, Alain Prigent, Martin Samal
Seminars in Nuclear Medicine 2008, 38 (1): 82-102
This report is the conclusion of the international consensus committee on renal transit time (subcommittee of the International Scientific Committee of Radionuclides in Nephrourology) and provides recommendations on measurement, normal values, and analysis of clinical utility. Transit time is the time that a tracer remains within the kidney or within a part of the kidney (eg, parenchymal transit time). It can be obtained from a dynamic renogram and a vascular input acquired in standardized conditions by a deconvolution process. Alternatively to transit time measurement, simpler indices were proposed, such as time of maximum, normalized residual activity or renal output efficiency. Transit time has been mainly used in urinary obstruction, renal artery stenosis, or renovascular hypertension and renal transplant. Despite a large amount of published data on obstruction, only the value of normal transit is established. The value of delayed transit remains controversial, probably due to lack of a gold standard for obstruction. Transit time measurements are useful to diagnose renovascular hypertension, as are some of the simpler indices. The committee recommends further collaborative trials.

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