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Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.

Kiev S Ly, Michael A Letavic, John M Keith, Jennifer M Miller, Emily M Stocking, Ann J Barbier, Pascal Bonaventure, Brian Lord, Xiaohui Jiang, Jamin D Boggs, Lisa Dvorak, Kirsten L Miller, Diane Nepomuceno, Sandy J Wilson, Nicholas I Carruthers
Bioorganic & Medicinal Chemistry Letters 2008 January 2
The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H3 ligands and serotonin reuptake inhibitors.

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