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Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't
Combining multiple optical trapping with microflow manipulation for the rapid bioanalytics on microparticles in a chip.
Review of Scientific Instruments 2007 November
An array of four independent laser traps is combined with a polydimethylsiloxane microfluidic chip to form a very compact system allowing parallel processing of biological objects. Strong three dimensional trapping allows holding objects such as functionalized beads in flows at speeds near 1 mm/s, enabling rapid processing. By pressure control of the inlet flows, the trapped objects can be put in contact with different solutions for analysis purpose. This setup, including a fluorescence excitation-detection scheme, offers the potential to perform complex biochemical manipulations on an ensemble of microparticles.
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