[Transfusion-related acute lung injury (TRALI)]

Ulrich J H Sachs, Gregor Bein
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS 2007, 42 (11): 774-82
According to data of international hemovigilance registries, transfusion-related acute lung injury (TRALI) has emerged as the leading cause of transfusion-related mortality. Errors in the transfusion process, leading to ABO incompatible transfusion, represent the second most frequent cause of transfusion-related mortality, while infection risks of transfusion declined significantly. The following article describes the clinical picture of TRALI, its pathogenesis, diagnostic criteria as well as therapy recommendations and discusses possible preventing measures.

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