Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru

Zhiyong Zhou, Sean M Griffing, Alexandre Macedo de Oliveira, Andrea M McCollum, Wilmer Marquino Quezada, Nancy Arrospide, Ananias A Escalante, Venkatachalam Udhayakumar
Antimicrobial Agents and Chemotherapy 2008, 52 (2): 739-41
The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.


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