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JOURNAL ARTICLE
REVIEW
Recent developments in the chemistry, analysis and control for the manufacture of therapeutic-grade synthetic oligonucleotides.
Current Opinion in Drug Discovery & Development 2007 November
Significant developments in oligonucleotide chemistry, which occurred between 1980 and 2000, led to several oligonucleotide-based therapeutics entering clinical trials. Improvements in synthesis and purification methods, along with analytical techniques have facilitated the large-scale manufacture of high quality oligonucleotides to support these clinical trials.
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