We have located links that may give you full text access.
Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Multicenter survey of diabetic pregnancy in France. Gestation and Diabetes in France Study Group.
Diabetes Care 1991 November
OBJECTIVE: To describe the medical care and outcome of diabetic pregnancy and gestational diabetes in France and study their associations with glycemic control.
RESEARCH DESIGN AND METHODS: We performed a multicenter prospective survey with systematic collection of clinical and biological data (HbA1c analysis in a central laboratory) at five successive examinations and consecutive recruitment of women at any stage of pregnancy in 46 specialized centers from all parts of France. Pregnancies were followed to the end. There were 483 single pregnancies (232 women with insulin-dependent diabetes mellitus [IDDM], 78 with non-insulin-dependent diabetes mellitus [NIDDM], and 173 with gestational diabetes mellitus [GDM]), and 11 twin births (8 IDDM, 3 GDM).
RESULTS: We observed 30 abortions (6%), 8 perinatal deaths (1.8%, 4 IDDM, 4 GDM), and 13 congenital malformations (3%). In the 11 twin pregnancies, there were 7 congenital malformations. Premature births and cesarean sections were found very frequently (42 and 61% IDDM, 29 and 55% NIDDM, 22 and 32% GDM, respectively). In the three groups, birth weight adjusted for gestational age was much greater than national reference values. HbA1c levels during the first trimester were significantly higher in women who aborted (mean +/- SE 7.1 +/- 0.4 vs. 5.6 +/- 0.1%, P less than 0.001) and those who gave birth to malformed infants (6.8 +/- 0.4 vs. 5.9 +/- 0.1%, P less than 0.05).
CONCLUSIONS: Perinatal mortality was slightly higher in diabetic women than the general population (1.8 vs. 1.2%), but the prematurity rate was much higher, possibly due to an interventionist policy in some centers. Fetal loss and congenital malformations were associated with poor glycemic control.
RESEARCH DESIGN AND METHODS: We performed a multicenter prospective survey with systematic collection of clinical and biological data (HbA1c analysis in a central laboratory) at five successive examinations and consecutive recruitment of women at any stage of pregnancy in 46 specialized centers from all parts of France. Pregnancies were followed to the end. There were 483 single pregnancies (232 women with insulin-dependent diabetes mellitus [IDDM], 78 with non-insulin-dependent diabetes mellitus [NIDDM], and 173 with gestational diabetes mellitus [GDM]), and 11 twin births (8 IDDM, 3 GDM).
RESULTS: We observed 30 abortions (6%), 8 perinatal deaths (1.8%, 4 IDDM, 4 GDM), and 13 congenital malformations (3%). In the 11 twin pregnancies, there were 7 congenital malformations. Premature births and cesarean sections were found very frequently (42 and 61% IDDM, 29 and 55% NIDDM, 22 and 32% GDM, respectively). In the three groups, birth weight adjusted for gestational age was much greater than national reference values. HbA1c levels during the first trimester were significantly higher in women who aborted (mean +/- SE 7.1 +/- 0.4 vs. 5.6 +/- 0.1%, P less than 0.001) and those who gave birth to malformed infants (6.8 +/- 0.4 vs. 5.9 +/- 0.1%, P less than 0.05).
CONCLUSIONS: Perinatal mortality was slightly higher in diabetic women than the general population (1.8 vs. 1.2%), but the prematurity rate was much higher, possibly due to an interventionist policy in some centers. Fetal loss and congenital malformations were associated with poor glycemic control.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app