New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.

Clementina Manera, Maria Grazia Cascio, Veronica Benetti, Marco Allarà, Tiziano Tuccinardi, Adriano Martinelli, Giuseppe Saccomanni, Elisa Vivoli, Carla Ghelardini, Vincenzo Di Marzo, Pier Luigi Ferrarini

Bioorganic & Medicinal Chemistry Letters 2007 December 2

A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB(2) affinity and CB(2) versus CB(1) selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects.

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