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JOURNAL ARTICLE
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[Adaptive designs for clinical trial].

OBJECTIVE: In order to provide readers with general concepts and methodology on adaptive designs for clinical trial.

METHODS: Definition of adaptive designs for clinical trial and basic idea of adaptive adjustment were introduced through an example.

RESULTS: The relationship between adaptive designs and group sequential design was summarized. Ways to embody two basic statistical rules of clinical trial under adaptive adjustments setting were also introduced.

CONCLUSION: Adaptive designs provided clinical trial with a great flexibility, which could greatly improve the efficiency of clinical trial.

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