Impaired cortical and autonomic arousal during sleep in multiple system atrophy

Roberto Vetrugno, Roberto D'Angelo, Pietro Cortelli, Giuseppe Plazzi, Luca Vignatelli, Pasquale Montagna
Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 2007, 118 (11): 2512-8

OBJECTIVE: Periodic limb movements during sleep (PLMS) in Restless Legs Syndrome (RLS) are associated with arousals and stereotyped EEG and heart rate (HR) changes. We investigated PLMS-related EEG and HR variations in multiple system atrophy (MSA) in order to detect possible abnormalities in cortical and autonomic arousal responses.

METHODS: Ten patients with MSA were contrasted against ten patients with primary RLS. Cortical (EEG) and autonomic (HR) variations associated with PLMS during NREM sleep were analysed by means of Fast Fourier Transform and HR analysis. In addition, we analysed the cyclic alternating pattern (CAP) during sleep, CAP representing a measure of the spontaneous arousal oscillations during NREM sleep.

RESULTS: PLMS in RLS were associated with tachycardia and spectral EEG variations, beginning about 2s before the onset of PLMS, and peaking 1-4s after. The HR and spectral EEG variations were strikingly reduced or absent in MSA. MSA patients also had significantly lower CAP rate compared to RLS patients.

CONCLUSIONS: Blunted HR and EEG spectral changes adjacent to PLMS indicated impaired cortical and autonomic arousal responses during sleep in MSA patients.

SIGNIFICANCE: PLMS, when present, may represent a useful means to study the arousal responses during sleep.

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