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Journal Article
Research Support, Non-U.S. Gov't
Review
Contribution of analytical microscopies to human neurodegenerative diseases research (PSP and AD).
Mini Reviews in Medicinal Chemistry 2007 September
Using analytical microscopies we have observed an increase of Fe(2+) iron-induced oxidative stress inside pathological ferritin (Ft). This finding, together with the presence of Ft in myelinated axons associated with oligodendrocyte processes and myelin sheet fraying, suggests that a dysfunction of ferritin (a ferritinopathy) may be the non-specific aging-dependent pathogenic event responsible for neurodegenerative disease.
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