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High-flow nasal cannula as a device to provide continuous positive airway pressure in infants.

K L Spence, D Murphy, C Kilian, R McGonigle, R A Kilani
Journal of Perinatology : Official Journal of the California Perinatal Association 2007 December
OBJECTIVE: To measure the intrapharyngeal pressure (IPP) generated by high-flow nasal cannula (HFNC) at varying flow rates up to 5 l min(-1).

STUDY DESIGN: We studied 14 infants on HFNC or NCPAP using IPP manometry to measure the IPP generated at flows of 1, 2, 3, 4 and 5 l min(-1).

RESULT: On average flow rates of 1, 2, 3, 4 and 5 l min(-1) generated an IPP (cm of H(2)O) of 1.70+/-0.34, 1.75+/-0.2, 2.62+/-0.28, 3.78+/-0.44 and 4.84+/-0.51 respectively.

CONCLUSION: HFNC delivers significant IPP and is potentially a well-tolerated and viable option to provide CPAP at flows of > or = 3 min(-1) in infants with respiratory distress.

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