Isotretinoin as a treatment for axillary granular parakeratosis

Aaron K Compton, J Mark Jackson
Cutis; Cutaneous Medicine for the Practitioner 2007, 80 (1): 55-6
Granular parakeratosis is a condition presenting with hyperkeratotic plaques and papules that are confined to intertriginous body sites. The exact etiology is unknown, but chemical and mechanical irritation and a moist environment are potential factors. Numerous treatments have been attempted, yielding variable results. We present a case of axillary granular parakeratosis, previously unresponsive to topical treatment, that resolved after a 2-week regimen of isotretinoin. We conclude that treatment of axillary granular parakeratosis with isotretinoin is rapid and effective and should be considered in patients with no other contraindications to isotretinoin.

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