Cellular mechanisms of neuroinflammatory pain: the role of interleukin-1beta

Chun-Sung Sung, Chih-Shung Wong
Acta Anaesthesiologica Taiwanica: Official Journal of the Taiwan Society of Anesthesiologists 2007, 45 (2): 103-9
Dorsal horn of the spinal cord is important in the transduction and modulation of various pain signals. Interleukin-1beta (IL-1beta) not only plays an important role in the nociceptive modulation but also enhances the spinal cord nociceptive neuron wind-up. Intrathecal (i.t.) administration of IL-1beta activates p38 mitogen-activated protein kinase (MAPK), and leads to induction of inducible nitric oxide synthase (iNOS) and release of nitric oxide (NO), which sensitizes the spinal nociceptors and produces thermal hyperalgesia and allodynia. I.t. pretreatment of IL-1 receptor antagonist (IL-1ra), p38 MAPK inhibitor or iNOS inhibitor, inhibits the i.t. IL-1beta-induced NO levels and thermal hyperalgesia in rats, likely via either inhibiting the IL-1beta-mediated p38 MAPK activation and subsequent iNOS induction, or direct attenuation of the central iNOS activity, which therefore reduces the central sensitization of inflammatory pain. I.t. administration of IL-1beta in rats provides an attractive model for studying the mechanisms and development of the treatment strategy of neuroinflammatory pain.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"