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JOURNAL ARTICLE

Five new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities

Sheng-Jun Dai, Gong-Fu Wang, Meng Chen, Ke Liu, Li Shen
Chemical & Pharmaceutical Bulletin 2007, 55 (8): 1218-21
17666848
Five new neo-clerodane diterpenoid alkaloids, named scutebarbatine G (1), 6,7-di-O-nicotinoylscutebarbatine G (2), 6-O-nicotinoyl-7-O-acetylscutebarbatine G (3), scutebarbatine H (4) and 7-O-nicotinoylscutebarbatine H (5) were isolated from the whole plant of Scutellaria barbata D. DON. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1-5 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC(50) values in the range 3.4-8.5 microM.

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