Safety of celecoxib in patients with cutaneous reactions due to ASA-NSAIDs intolerance

L Andri, P Falagiani
Allergologia et Immunopathologia 2007, 35 (4): 126-9

BACKGROUND: Pseudo-allergic reactions against aspirin (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) are quite frequent.

OBJECTIVE: Our aim was to determine tolerance of Celecoxib, a selective inhibitor of cyclooxygenase-2 (Cox-2), by oral challenge test in patients who showed skin reactions (diffuse erythema or urticaria/angioedema) after taking ASA and/or NSAIDs.

METHODS: The oral challenge test was carried out in single-blind on 86 patients treated with a 200 mg cumulative dose of Celebrex, administered in 3 or 4 visits at 48-72 hours interval.

RESULTS: Only 4 patients showed mild skin reactions. In addition, we observed 37 patients with osteoarthrosis taking a 200-400 mg/day dose of Celebrex 5-6 times a week, over a period of 75 days. At day 36, we observed in a single patient urticarial phenomena appeared on the chest and the back.

CONCLUSIONS: Our study proves therefore Celecoxib safety on a 72-hour observation period.

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