EPR study of the interactions between dendrimers and peptides involved in Alzheimer's and prion diseases

Barbara Klajnert, Michela Cangiotti, Sara Calici, Jean Pierre Majoral, Anne Marie Caminade, Josep Cladera, Maria Bryszewska, Maria Francesca Ottaviani
Macromolecular Bioscience 2007 August 7, 7 (8): 1065-74
Spin-probe and spin-label techniques were used to study the interactions of the Abeta 1-28 peptide involved in Alzheimer disease and the PrP 106-126 peptide suspected to be preferentially involved in spongiform encephalopathies with three different types of dendrimers. A computer-aided EPR analysis of a positively charged and a neutral spin probe was performed by comparing the pure dendrimer and peptide systems with the dendrimer-peptide ones. Also spin-labeled PAMAM dendrimers were used to test the interactions. The results show the interactions between dendrimer and peptide monomer to be stronger for Abeta 1-28 than for PrP 106-126. PAMAM dendrimers perturb the aggregation of the peptides more than PPI dendrimers do.

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