Modulation of spiral wave reentry by K(+) channel blockade

Haruo Honjo, Masatoshi Yamazaki, Kaichiro Kamiya, Itsuo Kodama
Circulation Journal: Official Journal of the Japanese Circulation Society 2007, 71: A26-31
It is well established that spiral wave reentry is the primary mechanism of ventricular tachyarrhythmias (ventricular fibrillation/tachycardia, VF/VT), but information is still limited concerning pharmacological modification of spiral waves by ion channel blockers. In this brief review, the antiarrhythmic and proarrhythmic actions of K(+)-channel blockade (I(Kr) and I (K1)) are discussed in terms of spiral wave dynamics, primarily based on recent experimental findings in ventricular preparations perfused in vitro with the aid of high-resolution optical mapping, as well as their related theoretical studies using computer simulation.

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