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Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study.

Andrew H Kemp, Kim Felmingham, Pritha Das, Gerard Hughes, Anthony S Peduto, Richard A Bryant, Leanne M Williams
Psychiatry Research 2007 August 16
Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal-amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity.

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