Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death

Sana M Al-Khatib, Gillian D Sanders, J Thomas Bigger, Alfred E Buxton, Robert M Califf, Mark Carlson, Anne Curtis, Jeptha Curtis, Eric Fain, Bernard J Gersh, Michael R Gold, Ali Haghighi-Mood, Stephen C Hammill, Jeff Healey, Mark Hlatky, Stefan Hohnloser, Raymond J Kim, Kerry Lee, Daniel Mark, Marcus Mianulli, Brent Mitchell, Eric N Prystowsky, Joseph Smith, David Steinhaus, Wojciech Zareba et al.
American Heart Journal 2007, 153 (6): 941-50
17540194
Accurate and timely prediction of sudden cardiac death (SCD) is a necessary prerequisite for effective prevention and therapy. Although the largest number of SCD events occurs in patients without overt heart disease, there are currently no tests that are of proven predictive value in this population. Efforts in risk stratification for SCD have focused primarily on predicting SCD in patients with known structural heart disease. Despite the ubiquity of tests that have been purported to predict SCD vulnerability in such patients, there is little consensus on which test, in addition to the left ventricular ejection fraction, should be used to determine which patients will benefit from an implantable cardioverter defibrillator. On July 20 and 21, 2006, a group of experts representing clinical cardiology, cardiac electrophysiology, biostatistics, economics, and health policy were joined by representatives of the US Food and Drug administration, Centers for Medicare Services, Agency for Health Research and Quality, the Heart Rhythm Society, and the device and pharmaceutical industry for a round table meeting to review current data on strategies of risk stratification for SCD, to explore methods to translate these strategies into practice and policy, and to identify areas that need to be addressed by future research studies. The meeting was organized by the Duke Center for the Prevention of SCD at the Duke Clinical Research Institute and was funded by industry participants. This article summarizes the presentations and discussions that occurred at that meeting.

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