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Randomized Controlled Trial
Research Support, Non-U.S. Gov't
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Treatment of spinocerebellar ataxia with buspirone.

Mitra Assadi, Joseph V Campellone, Christopher G Janson, J Jon Veloski, Robert J Schwartzman, Paola Leone
Journal of the Neurological Sciences 2007 September 15
Preliminary data suggest potential benefit of 5-HT receptor agonists in the treatment of ataxias. We studied the effects of buspirone in a cohort of twenty patients with spinocerebellar ataxia (SCA). Twenty patients were treated in this double-blind, placebo controlled, cross-over trial with either buspirone HCl 30 mg twice daily or placebo for 3 months. Buspirone was not shown to be superior to placebo in the treatment of patients with SCA.

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