A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies

Yves Roggo, Pascal Chalus, Lene Maurer, Carmen Lema-Martinez, Aurélie Edmond, Nadine Jent
Journal of Pharmaceutical and Biomedical Analysis 2007 July 27, 44 (3): 683-700
Near-infrared spectroscopy (NIRS) is a fast and non-destructive analytical method. Associated with chemometrics, it becomes a powerful tool for the pharmaceutical industry. Indeed, NIRS is suitable for analysis of solid, liquid and biotechnological pharmaceutical forms. Moreover, NIRS can be implemented during pharmaceutical development, in production for process monitoring or in quality control laboratories. This review focuses on chemometric techniques and pharmaceutical NIRS applications. The following topics are covered: qualitative analyses, quantitative methods and on-line applications. Theoretical and practical aspects are described with pharmaceutical examples of NIRS applications.

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