Comparative environmental genomics in non-model species: using heterologous hybridization to DNA-based microarrays

Bradley A Buckley
Journal of Experimental Biology 2007, 210: 1602-6
The emerging field of comparative environmental genomics involves the cross-species comparison of broad-scale patterns of gene expression. Often, the goal is to elucidate the evolutionary basis or ecological implications of genomic responses to environmental stimuli. DNA-based microarrays represent powerful means with which to investigate gene expression, and the application of genomic tools to studies on non-model species is becoming increasingly feasible. The use of a microarray generated from one species to probe gene expression in another, a method termed 'heterologous hybridization', eliminates the need to fabricate novel microarray platforms for every new species of interest. In this review, recent advances in heterologous hybridization are reviewed, and the technical caveats of this approach are discussed.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"